SnapShot: Lysosomal Functions

SnapShot: mTORC1 Signaling at the Lysosomal Surface

Optimal snapshot location for computing POD basis functions

The construction of reduced order models for dynamical systems using proper orthogonal decomposition (POD) is based on the information contained in so-called snapshots. These provide the spatial distribution of the dynamical system at discrete time instances. This work is devoted to optimizing the choice of these time instances in such a manner that the error between the POD-solution and the tr...

Involvement of Lysosomal Labilisation and Lysosomal/mitochondrial Cross-Talk in Diclofenac Induced Hepatotoxicity

In this research, we investigated the cytotoxic mechanisms of one of the widely used pharmaceuticals that are regularly associated with the adverse effects on the liver, sometimes leading to acute liver failure, diclofenac. Diclofenac liver cytotoxicity was associated with reactive oxygen species (ROS) formation and lipid peroxidation which were inhibited by antioxidants and ROS scavengers, fer...

Involvement of Lysosomal Labilisation and Lysosomal/mitochondrial Cross-Talk in Diclofenac Induced Hepatotoxicity

In this research, we investigated the cytotoxic mechanisms of one of the widely used pharmaceuticals that are regularly associated with the adverse effects on the liver, sometimes leading to acute liver failure, diclofenac. Diclofenac liver cytotoxicity was associated with reactive oxygen species (ROS) formation and lipid peroxidation which were inhibited by antioxidants and ROS scavengers, fer...

Ageing-associated changes of lysosomal compartment – implications on cellular functions

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